Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia
Objective: Mice with congenital loss of the glucagon receptor gene (Gcgr−/− mice) remain normoglycemic in insulinopenic conditions, suggesting that unopposed glucagon action is the driving force for hyperglycemia in Type-1 Diabetes Mellitus (T1DM). However, chronic loss of GCGR results in a neomorph...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
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Elsevier,
2018-11-01T00:00:00Z.
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