Ethanol Extract of Brucea javanica Seed Inhibit Triple-Negative Breast Cancer by Restraining Autophagy via PI3K/Akt/mTOR Pathway

• Main Authors: Xiaohong Chen (Author), Shuang Li (Author), Dan Li (Author), Muxia Li (Author), Ziren Su (Author), Xiaoping Lai (Author), Changlin Zhou (Author), Shaodan Chen (Author), Shunxian Li (Author), Xiaobing Yang (Author), Jiyan Su (Author), Yunjian Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triple-negative breast cancer (TNBC) is an aggressive disease with worst prognosis than other subtypes of breast cancer. Owing to the lack of hormone receptors and HER2 expression on TNBC cells, patients do not have targeted therapy options available with other breast cancer subtypes. Extensive effo...