Dual Action of the PN159/KLAL/MAP Peptide: Increase of Drug Penetration across Caco-2 Intestinal Barrier Model by Modulation of Tight Junctions and Plasma Membrane Permeability

• Main Authors: Alexandra Bocsik (Author), Ilona Gróf (Author), Lóránd Kiss (Author), Ferenc Ötvös (Author), Ottó Zsíros (Author), Lejla Daruka (Author), Lívia Fülöp (Author), Monika Vastag (Author), Ágnes Kittel (Author), Norbert Imre (Author), Tamás A. Martinek (Author), Csaba Pál (Author), Piroska Szabó-Révész (Author), Mária A. Deli (Author)
• Format: Book
• Published: MDPI AG, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The absorption of drugs is limited by the epithelial barriers of the gastrointestinal tract. One of the strategies to improve drug delivery is the modulation of barrier function by the targeted opening of epithelial tight junctions. In our previous study the 18-mer amphiphilic PN159 peptide was foun...