Disruption of DDX53 coding sequence has limited impact on iPSC-derived human NGN2 neurons

• Main Authors: Muhammad Faheem (Author), Eric Deneault (Author), Roumiana Alexandrova (Author), Deivid C. Rodrigues (Author), Giovanna Pellecchia (Author), Carole Shum (Author), Mehdi Zarrei (Author), Alina Piekna (Author), Wei Wei (Author), Jennifer L. Howe (Author), Bhooma Thiruvahindrapuram (Author), Sylvia Lamoureux (Author), P. Joel Ross (Author), Clarrisa A. Bradley (Author), James Ellis (Author), Stephen W. Scherer (Author)
• Format: Book
• Published: BMC, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The X-linked PTCHD1 locus is strongly associated with autism spectrum disorder (ASD). Males who carry chromosome microdeletions of PTCHD1 antisense long non-coding RNA (PTCHD1-AS)/DEAD-box helicase 53 (DDX53) have ASD, or a sub-clinical form called Broader Autism Phenotype. If th...