Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitro

• Main Authors: Masahiro Sasaki (Author), Takefumi Ito (Author), Masayuki Kashima (Author), Shin Fukui (Author), Noriko Izumiyama (Author), Akiko Watanabe (Author), Masaaki Sano (Author), Yosimasa Fujiwara (Author), Mamoru Miura (Author)
• Format: Book
• Published: Hindawi Limited, 2001-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heparanase activity is correlated with the metastatic potential of several cancer cells and is a key enzyme in the breakdown of tissue barriers. It is also involved in the regulation of growth factor and cytokine activity. However, little is known about the factors that induce heparanase in cancer c...