Sodium pyruvate exerts protective effects against cigarette smoke extract-induced ferroptosis in alveolar and bronchial epithelial cells through the GPX4/Nrf2 axis

• Main Authors: Ziwen Zhao (Author), Zhao Xu (Author), Jingwen Chang (Author), Liwei He (Author), Zijin Zhang (Author), Xiaoyu Song (Author), Xianbang Hou (Author), Fangtian Fan (Author), Zhijun Jiang (Author)
• Format: Book
• Published: BMC, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Ferroptosis in alveolar and bronchial epithelial cells is one of the main mechanisms underlying the development of chronic obstructive pulmonary disease (COPD). Sodium pyruvate (NaPyr) is a natural antioxidant in the body, exhibiting anti-inflammatory and antioxidant activities....