An entire exon 3 germ-line rearrangement in the <it>BRCA2 </it>gene: pathogenic relevance of exon 3 deletion in breast cancer predisposition

• Main Authors: Demange Liliane (Author), Limacher Jean (Author), Noguès Catherine (Author), Caron Olivier (Author), Bièche Ivan (Author), Lefol Cédrick (Author), Caputo Sandrine (Author), Schultz Inès (Author), Rouleau Etienne (Author), Muller Danièle (Author), Lidereau Rosette (Author), Fricker Jean (Author), Abecassis Joseph (Author)
• Format: Knjiga
• Izdano: BMC, 2011-09-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Germ-line mutations in the <it>BRCA1 </it>and <it>BRCA2 </it>genes are major contributors to hereditary breast/ovarian cancer. Large rearrangements are less frequent in the <it>BRCA2 </it>gene than...