A novel integrated QSP model of in vivo human glucose regulation to support the development of a glucagon/GLP‐1 dual agonist

• Үндсэн зохиолчид: Rolien Bosch (Зохиогч), Marcella Petrone (Зохиогч), Rosalin Arends (Зохиогч), Paolo Vicini (Зохиогч), Eric J. G. Sijbrands (Зохиогч), Sven Hoefman (Зохиогч), Nelleke Snelder (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Wiley, 2022-03-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists (GLP‐1RAs) and dual GLP‐1/glucagon receptor agonists improve glycaemic control and cause significant weight loss in patients with type 2 diabetes.1 These effects are driven in part by augmenting glucose‐stimulated insulin release (incretin e...