Mus musculus deficient for secretory antibodies show delayed growth with an altered urinary metabolome

• Main Authors: Kim R. Simpfendorfer (Author), Nancy Wang (Author), Dedreia L. Tull (Author), David P. De Souza (Author), Amsha Nahid (Author), Andre Mu (Author), Dianna M. Hocking (Author), John S. Pedersen (Author), Odilia L. C. Wijburg (Author), Malcolm J. McConville (Author), Richard A. Strugnell (Author)
• Format: Bog
• Udgivet: BMC, 2019-04-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Abstract Background The polymeric immunoglobulin receptor (pIgR) maintains the integrity of epithelial barriers by transporting polymeric antibodies and antigens through the epithelial mucosa into the lumen. In this study, we examined the role of pIgR in maintaining gut barrier integrity, which is i...