Blockade of voltage-dependent K+ current in rabbit coronary arterial smooth muscle cells by the tricyclic antidepressant clomipramine

• Autori principali: Hongliang Li (Autore), Sung Eun Shin (Autore), Jin Ryeol An (Autore), Mi Seon Seo (Autore), Kwon-Soo Ha (Autore), Eun-Taek Han (Autore), Seok-Ho Hong (Autore), Amy L. Firth (Autore), Dae-Sung Lee (Autore), Mi-Jin Yim (Autore), Jeong Min Lee (Autore), Grace Choi (Autore), Il-Whan Choi (Autore), Won Sun Park (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2018-05-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

We investigated the effect of the tricyclic antidepressant clomipramine on voltage-dependent K+ (Kv) channels in native rabbit coronary arterial smooth muscle cells. Our results showed that clomipramine inhibited vascular Kv channels in a concentration-dependent manner, with an IC50 value of 8.61 ± ...