Combined Antagonism of 5-HT₂ and NMDA Receptors Reduces the Aggression of Monoamine Oxidase a Knockout Mice

• Main Authors: Roberto Frau (Author), Alessandra Pardu (Author), Sean Godar (Author), Valentina Bini (Author), Marco Bortolato (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The enzyme monoamine oxidase A (MAOA) catalyzes the degradation of several neurotransmitters, including serotonin. A large body of evidence has shown that genetic MAOA deficiency predisposes humans and mice to aggression and antisocial behavior. We previously documented that the aggression of male M...