Virus-like particle vaccine displaying an external, membrane adjacent MUC16 epitope elicits ovarian cancer-reactive antibodies

• Main Authors: Hsin-Fang Tu (Author), Margaret Wong (Author), Ssu-Hsueh Tseng (Author), Nattha Ingavat (Author), Pola Olczak (Author), Kin Israel Notarte (Author), Chien-fu Hung (Author), Richard B.S. Roden (Author)
• Format: Book
• Published: BMC, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background MUC16 is a heavily glycosylated cell surface mucin cleaved in the tumor microenvironment to shed CA125. CA125 is a serum biomarker expressed by > 95% of non-mucinous advanced stage epithelial ovarian cancers. MUC16/CA125 contributes to the evasion of anti-tumor immunity, perit...