Luteolin Binds Streptolysin O Toxin and Inhibits Its Hemolytic Effects and Cytotoxicity

• Main Authors: Tingting Guo (Author), Peng Liu (Author), Zeyu Wang (Author), Yuling Zheng (Author), Wenhua Huang (Author), Decong Kong (Author), Lizhong Ding (Author), Qingyu Lv (Author), Zhongtian Wang (Author), Hua Jiang (Author), Yongqiang Jiang (Author), Liping Sun (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Group A streptococcus (GAS, Streptococcus pyogenes) is a common pathogen that can cause a variety of human diseases. Streptolysin O (SLO) is an exotoxin produced by GAS. It is a pore-forming toxin (PFT) that exhibits high in vivo toxicity. SLO enables GAS to evade phagocytosis and clearance by neutr...