Spanlastics as a Potential Platform for Enhancing the Brain Delivery of Flibanserin: In Vitro Response-Surface Optimization and In Vivo Pharmacokinetics Assessment

• Main Authors: Waleed S. Alharbi (Author), Rawan H. Hareeri (Author), Mohammed Bazuhair (Author), Mohamed A. Alfaleh (Author), Nabil A. Alhakamy (Author), Usama A. Fahmy (Author), Abdullah A. Alamoudi (Author), Shaimaa M. Badr-Eldin (Author), Osama A. Ahmed (Author), Shareefa A. AlGhamdi (Author), Marianne J. Naguib (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Flibanserin was licensed by the United States Food and Drug Administration (FDA) as an oral non-hormonal therapy for pre-menopausal women with inhibited sexual desire disorder. However, it suffers from susceptibility to first-pass metabolism in the liver, low aqueous solubility, and degradation in t...