Pharmacological treatment and BBB-targeted genetic therapy for MCT8-dependent hypomyelination in zebrafish

• Hoofdauteurs: David Zada (Auteur), Adi Tovin (Auteur), Tali Lerer-Goldshtein (Auteur), Lior Appelbaum (Auteur)
• Formaat: Boek
• Gepubliceerd in: The Company of Biologists, 2016-11-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Hypomyelination is a key symptom of Allan-Herndon-Dudley syndrome (AHDS), a psychomotor retardation associated with mutations in the thyroid-hormone (TH) transporter MCT8 (monocarboxylate transporter 8). AHDS is characterized by severe intellectual deficiency, neuromuscular impairment and brain hypo...