Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota

• Main Authors: Yue Zhang (Author), Jianliang Geng (Author), Yu Hong (Author), Li Jiao (Author), Shuning Li (Author), Runbin Sun (Author), Yuan Xie (Author), Caixia Yan (Author), Jiye Aa (Author), Guangji Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our pilot study suggested that orally administered crocin was hardly absorbed into circulatory system, but it was effective against cerebral ischemic/reperfusion (I/R) injury. The pharmacologically active component and targeting site of crocin remain elusive. In this study, the cerebral-protective e...