The development of 177Lu-DOTA-CC-PSMA following a unified "Click Chemistry" protocol of synthesizing metal nuclide-conjugated radiopharmaceuticals

• Main Authors: Xiaobei Zheng (Author), Shuai Xue (Author), Zhongqi Zhao (Author), Shuxin Jin (Author), Shuhua He (Author), Lina Jia (Author), Zheng Li (Author), Christian Vanhove (Author), Filip De Vos (Author), Zijun Kuang (Author), Tiantian Wang (Author), Sara Neyt (Author), Lan Zhang (Author), Xiao Li (Author)
• Format: Book
• Published: SpringerOpen, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Currently, the synthesis pathway of metal nuclide-labeled radiopharmaceuticals is mainly divided into two steps: first, connecting the chelator with the target molecule, and second, labeling the metal nuclide to the chelator. However, the second step of the reaction to label the...