Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet

• Main Authors: Joely A. Kellard (Author), Nils J.G. Rorsman (Author), Thomas G. Hill (Author), Sarah L. Armour (Author), Martijn van de Bunt (Author), Patrik Rorsman (Author), Jakob G. Knudsen (Author), Linford J.B. Briant (Author)
• Format: Book
• Published: Elsevier, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Elevated plasma glucagon is an early symptom of diabetes, occurring in subjects with impaired glucose regulation. Here, we explored alpha-cell function in female mice fed a high-fat diet (HFD). Methods: Female mice expressing the Ca2+ indicator GCaMP3 specifically in alpha-cells were fed...