Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet

• मुख्य लेखकों: Joely A. Kellard (लेखक), Nils J.G. Rorsman (लेखक), Thomas G. Hill (लेखक), Sarah L. Armour (लेखक), Martijn van de Bunt (लेखक), Patrik Rorsman (लेखक), Jakob G. Knudsen (लेखक), Linford J.B. Briant (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2020-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objectives: Elevated plasma glucagon is an early symptom of diabetes, occurring in subjects with impaired glucose regulation. Here, we explored alpha-cell function in female mice fed a high-fat diet (HFD). Methods: Female mice expressing the Ca2+ indicator GCaMP3 specifically in alpha-cells were fed...