Synthesis and biological evaluation of novel thienopyrimidine derivatives as diacylglycerol acyltransferase 1 (DGAT-1) inhibitors

• Κύριοι συγγραφείς: Dong Jin Hong (Συγγραφέας), Seung Hyun Jung (Συγγραφέας), Jisook Kim (Συγγραφέας), Danbee Jung (Συγγραφέας), Young Gil Ahn (Συγγραφέας), Kwee Hyun Suh (Συγγραφέας), Kyung Hoon Min (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

A novel series of thieno[3,2-d]pyrimidine derivatives were synthesised and their inhibitory effects against diacylglycerol acyltransferase 1 (DGAT-1) were assessed. cis-Isomer 17a showed potent and selective inhibitory activity against DGAT-1 in SF9 cells. In addition, 17a had an acceptable pharmaco...