Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing

• Main Authors: Lucie Desmoulins (Author), Chloé Chrétien (Author), Romain Paccoud (Author), Stephan Collins (Author), Céline Cruciani-Guglielmacci (Author), Anne Galinier (Author), Fabienne Liénard (Author), Aurore Quinault (Author), Sylvie Grall (Author), Camille Allard (Author), Claire Fenech (Author), Lionel Carneiro (Author), Thomas Mouillot (Author), Audren Fournel (Author), Claude Knauf (Author), Christophe Magnan (Author), Xavier Fioramonti (Author), Luc Pénicaud (Author), Corinne Leloup (Author)
• Format: Book
• Published: Elsevier, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Hypothalamic glucose sensing (HGS) initiates insulin secretion (IS) via a vagal control, participating in energy homeostasis. This requires mitochondrial reactive oxygen species (mROS) signaling, dependent on mitochondrial fission, as shown by invalidation of the hypothalamic DRP1 protein...