Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres

• Main Authors: Roberta eCarbonara (Author), Alessia eCarocci (Author), Julien eRoussel (Author), Giuseppe eCrescenzo (Author), Canio eBuonavoglia (Author), Carlo eFranchini (Author), Giovanni eLentini (Author), Diana eConte Camerino (Author), Jean-François eDesaphy (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Voltage-gated sodium channels are known to play a pivotal role in perception and transmission of pain sensations. Gain-of-function mutations in the genes encoding the peripheral neuronal sodium channels, hNav1.7-1.9, cause human painful diseases. Thus while treatment of chronic pain remains an unmet...