ASOptimizer: Optimizing antisense oligonucleotides through deep learning for IDO1 gene regulation

• Main Authors: Gyeongjo Hwang (Author), Mincheol Kwon (Author), Dongjin Seo (Author), Dae Hoon Kim (Author), Daehwan Lee (Author), Kiwon Lee (Author), Eunyoung Kim (Author), Mingeun Kang (Author), Jin-Hyeob Ryu (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent studies have highlighted the effectiveness of using antisense oligonucleotides (ASOs) for cellular RNA regulation, including targets that are considered undruggable; however, manually designing optimal ASO sequences can be labor intensive and time consuming, which potentially limits their bro...