Cocrystal of Ibuprofen-Nicotinamide: Solid-State Characterization and In Vivo Analgesic Activity Evaluation

• Main Authors: Yori Yuliandra (Author), Erizal Zaini (Author), Syofyan Syofyan (Author), Wenny Pratiwi (Author), Lidiya Novita Putri (Author), Yuti Sahra Pratiwi (Author), Helmi Arifin (Author)
• Format: Book
• Published: MDPI AG, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ibuprofen is classified as a BCS class II drug which has low solubility and high permeability. We conducted the formation of the cocrystalline phase of ibuprofen with coformer nicotinamide to increase its solubility. The purpose of this study was to characterize the solid state of cocrystalline phas...