Roxadustat, a Hypoxia-Inducible Factor 1α Activator, Attenuates Both Long- and Short-Term Alcohol-Induced Alcoholic Liver Disease

• Main Authors: Yongyao Gao (Author), Xiaomeng Jiang (Author), Daigang Yang (Author), Wentong Guo (Author), Dandan Wang (Author), Ke Gong (Author), Ying Peng (Author), Hong Jiang (Author), Cunyuan Shi (Author), Yajun Duan (Author), Yuanli Chen (Author), Jihong Han (Author), Xiaoxiao Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alcoholic liver disease (ALD) is a worldwide healthcare problem featured by inflammation, reactive oxygen species (ROS), and lipid dysregulation. Roxadustat is used for chronic kidney disease anemia treatment. As a specific inhibitor of prolyl hydroxylase, it can maintain high levels of hypoxia-indu...