Assessing the performance of European-derived cardiometabolic polygenic risk scores in South-Asians and their interplay with family history

• Main Authors: Emadeldin Hassanin (Author), Carlo Maj (Author), Hannah Klinkhammer (Author), Peter Krawitz (Author), Patrick May (Author), Dheeraj Reddy Bobbili (Author)
• Format: Book
• Published: BMC, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background & aims We aimed to assess the performance of European-derived polygenic risk scores (PRSs) for common metabolic diseases such as coronary artery disease (CAD), obesity, and type 2 diabetes (T2D) in the South Asian (SAS) individuals in the UK Biobank. Additionally, we studied...