Estimating peptide half‐life in serum from tunable, sequence‐related physicochemical properties

• Päätekijät: Marco Cavaco (Tekijä), Javier Valle (Tekijä), Isabel Flores (Tekijä), David Andreu (Tekijä), Miguel A. R. B. Castanho (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Wiley, 2021-07-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Abstract Proteolytic instability is a critical limitation for peptide‐based products. Although significant efforts are devoted to stabilize sequences against proteases/peptidases in plasma/serum, such approaches tend to be rather empirical, unspecific, time‐consuming, and frequently not cost‐effecti...