ATP Induces IL-1β Secretion in Neisseria gonorrhoeae-Infected Human Macrophages by a Mechanism Not Related to the NLRP3/ASC/Caspase-1 Axis

• Main Authors: Killen García (Author), Gisselle Escobar (Author), Pablo Mendoza (Author), Caroll Beltran (Author), Claudio Perez (Author), Sergio Arancibia (Author), Rolando Vernal (Author), Paula I. Rodas (Author), Claudio Acuña-Castillo (Author), Alejandro Escobar (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neisseria gonorrhoeae (Ngo) has developed multiple immune evasion mechanisms involving the innate and adaptive immune responses. Recent findings have reported that Ngo reduces the IL-1β secretion of infected human monocyte-derived macrophages (MDM). Here, we investigate the role of adenosine triphos...