Dual inhibition of MYC and SLC39A10 by a novel natural product STAT3 inhibitor derived from Chaetomium globosum suppresses tumor growth and metastasis in gastric cancer

• Main Authors: Xiaoqing Guan (Author), Jing Yang (Author), Weiyi Wang (Author), Bing Zhao (Author), Shiyu Hu (Author), Dehua Yu (Author), Li Yuan (Author), Yunfu Shi (Author), Jingli Xu (Author), Jinyun Dong (Author), Jinxin Wang (Author), Xiang-Dong Cheng (Author), Jiang-Jiang Qin (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gastric cancer remains one of the most common deadly diseases and lacks effective targeted therapies. In the present study, we confirmed that the signal transducer and activator of transcription 3 (STAT3) is highly expressed and associated with a poor prognosis in gastric cancer. We further identifi...