A New Quantitative Cell-Based Assay Reveals Unexpected Microtubule Stabilizing Activity of Certain Kinase Inhibitors, Clinically Approved or in the Process of Approval

• Hoofdauteurs: Sacnicte Ramirez-Rios (Auteur), Sophie Michallet (Auteur), Leticia Peris (Auteur), Caroline Barette (Auteur), Clotilde Rabat (Auteur), Yangbo Feng (Auteur), Marie-Odile Fauvarque (Auteur), Annie Andrieux (Auteur), Karin Sadoul (Auteur), Laurence Lafanechère (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Onderwerpen: article
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Agents able to modify microtubule dynamics are important anticancer drugs. The absence of microtubules resulting from drug-induced depolymerization is easy to detect. However the detection of a stabilized microtubule network needs specific assays since there is not a significant visual difference be...