A New Quantitative Cell-Based Assay Reveals Unexpected Microtubule Stabilizing Activity of Certain Kinase Inhibitors, Clinically Approved or in the Process of Approval

• Main Authors: Sacnicte Ramirez-Rios (Author), Sophie Michallet (Author), Leticia Peris (Author), Caroline Barette (Author), Clotilde Rabat (Author), Yangbo Feng (Author), Marie-Odile Fauvarque (Author), Annie Andrieux (Author), Karin Sadoul (Author), Laurence Lafanechère (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Agents able to modify microtubule dynamics are important anticancer drugs. The absence of microtubules resulting from drug-induced depolymerization is easy to detect. However the detection of a stabilized microtubule network needs specific assays since there is not a significant visual difference be...