A New Quantitative Cell-Based Assay Reveals Unexpected Microtubule Stabilizing Activity of Certain Kinase Inhibitors, Clinically Approved or in the Process of Approval

• Egile Nagusiak: Sacnicte Ramirez-Rios (Egilea), Sophie Michallet (Egilea), Leticia Peris (Egilea), Caroline Barette (Egilea), Clotilde Rabat (Egilea), Yangbo Feng (Egilea), Marie-Odile Fauvarque (Egilea), Annie Andrieux (Egilea), Karin Sadoul (Egilea), Laurence Lafanechère (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Agents able to modify microtubule dynamics are important anticancer drugs. The absence of microtubules resulting from drug-induced depolymerization is easy to detect. However the detection of a stabilized microtubule network needs specific assays since there is not a significant visual difference be...