Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoni.

• Main Authors: Jessica R Ingram (Author), Salma B Rafi (Author), A Alegra Eroy-Reveles (Author), Manisha Ray (Author), Laura Lambeth (Author), Ivy Hsieh (Author), Debbie Ruelas (Author), K C Lim (Author), Judy Sakanari (Author), Charles S Craik (Author), Matthew P Jacobson (Author), James H McKerrow (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cercarial elastase is the major invasive larval protease in Schistosoma mansoni, a parasitic blood fluke, and is essential for host skin invasion. Genome sequence analysis reveals a greatly expanded family of cercarial elastase gene isoforms in Schistosoma mansoni. This expansion appears to be uniqu...