Cathepsin B-Overexpressed Tumor Cell Activatable Albumin-Binding Doxorubicin Prodrug for Cancer-Targeted Therapy

• Main Authors: Hanhee Cho (Author), Man Kyu Shim (Author), Suah Yang (Author), Sukyung Song (Author), Yujeong Moon (Author), Jinseong Kim (Author), Youngro Byun (Author), Cheol-Hee Ahn (Author), Kwangmeyung Kim (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Prodrugs are bioreversible medications that should undergo an enzymatic or chemical transformation in the tumor microenvironment to release active drugs, which improve cancer selectivity to reduce toxicities of anticancer drugs. However, such approaches have been challenged by poor therapeutic effic...