Therapeutic Potential of Targeting the PERK Signaling Pathway in Ischemic Stroke

• Main Authors: Xinyuan Yu (Author), Lihong Dang (Author), Ran Zhang (Author), Wei Yang (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Many pathologic states can lead to the accumulation of unfolded/misfolded proteins in cells. This causes endoplasmic reticulum (ER) stress and triggers the unfolded protein response (UPR), which encompasses three main adaptive branches. One of these UPR branches is mediated by protein kinase RNA-lik...