Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis

• Main Authors: Hsueh-Yuan Chang (Author), Shengjia Wu (Author), Yingyi Li (Author), Wanying Zhang (Author), Matthew Burrell (Author), Carl I. Webster (Author), Dhaval K. Shah (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Receptor-mediated transcytosis (RMT) is used to enhance the delivery of monoclonal antibodies (mAb) into the central nervous system (CNS). While the binding to endogenous receptors on the brain capillary endothelial cells (BCECs) may facilitate the uptake of mAbs in the brain, a strong affinity for...