Combination Treatment of Cervical Cancer Using Folate-Decorated, pH-Sensitive, Carboplatin and Paclitaxel Co-Loaded Lipid-Polymer Hybrid Nanoparticles
Junjian Wang 1–3 1Institution of Cancer and Basic Medicine, Chinese Academy of Sciences, Hangzhou 310022, Zhejiang Province, People’s Republic of China; 2Department of Gynecological Surgery, Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou 310022, Zhejia...
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2020-02-01T00:00:00Z.
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| 100 | 1 | 0 | |a Wang J |e author |
| 245 | 0 | 0 | |a Combination Treatment of Cervical Cancer Using Folate-Decorated, pH-Sensitive, Carboplatin and Paclitaxel Co-Loaded Lipid-Polymer Hybrid Nanoparticles |
| 260 | |b Dove Medical Press, |c 2020-02-01T00:00:00Z. | ||
| 500 | |a 1177-8881 | ||
| 520 | |a Junjian Wang 1–3 1Institution of Cancer and Basic Medicine, Chinese Academy of Sciences, Hangzhou 310022, Zhejiang Province, People’s Republic of China; 2Department of Gynecological Surgery, Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou 310022, Zhejiang Province, People’s Republic of China; 3Department of Gynecological Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, People’s Republic of ChinaCorrespondence: Junjian WangInstitution of Cancer and Basic Medicine, Chinese Academy of Sciences, No. 1 East Banshan Road, Gongshu District, Hangzhou City, Zhejiang Province, People’s Republic of ChinaEmail wangjunjian@protonmail.comPurpose: Cervical cancer is one of the most common causes of death among women globally. Combinations of cisplatin, paclitaxel, bevacizumab, carboplatin, topotecan, and gemcitabine are recommended as first-line therapies.Methods: This study focuses on the development of folate-decorated, pH-sensitive lipid-polymer hybrid nanoparticles (LPNs). Loading carboplatin (CBP) and paclitaxel (PTX), LPNs were expected to combine the therapeutic effects of CBP and PTX, thus show synergistic ability on cervical cancer.Results: FA-CBP/PTX-LPNs showed the sizes of 169.9 ± 5.6 nm, with a narrow size distribution of 0.151 ± 0.023. FA-CBP/PTX-LPNs exhibited pH-responsive drug release, high cellular uptake efficiency (66.7 ± 3.1%), and prominent cell inhibition capacity (23 ± 1.1%). In vivo tumor distribution and tumor inhibition efficiency of FA-CBP/PTX-LPNs was the highest, with no obvious body weight lost.Conclusion: High tumor distribution and remarkable antitumor efficiency obtained using in vitro as well as in vivo models further proved the FA-CBP/PTX-LPNs is a promising tool for cervical cancer therapy.Keywords: cervical cancer, folate, pH-sensitive, carboplatin, paclitaxel, lipid-polymer hybrid nanoparticles | ||
| 546 | |a EN | ||
| 690 | |a cervical cancer | ||
| 690 | |a folate | ||
| 690 | |a ph-sensitive | ||
| 690 | |a carboplatin | ||
| 690 | |a paclitaxel | ||
| 690 | |a lipid-polymer hybrid nanoparticles | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Drug Design, Development and Therapy, Vol Volume 14, Pp 823-832 (2020) | |
| 787 | 0 | |n https://www.dovepress.com/combination-treatment-of-cervical-cancer-using-folate-decorated-ph-sen-peer-reviewed-article-DDDT | |
| 787 | 0 | |n https://doaj.org/toc/1177-8881 | |
| 856 | 4 | 1 | |u https://doaj.org/article/add816c6b5b54e9c9b262783feb879c3 |z Connect to this object online. |