Adipocyte-specific FXR-deficiency protects adipose tissue from oxidative stress and insulin resistance and improves glucose homeostasis

• Main Authors: Hélène Dehondt (Author), Arianna Marino (Author), Laura Butruille (Author), Denis A. Mogilenko (Author), Arielle C. Nzoussi Loubota (Author), Oscar Chávez-Talavera (Author), Emilie Dorchies (Author), Emmanuelle Vallez (Author), Joel Haas (Author), Bruno Derudas (Author), Antonino Bongiovanni (Author), Meryem Tardivel (Author), Folkert Kuipers (Author), Philippe Lefebvre (Author), Sophie Lestavel (Author), Anne Tailleux (Author), David Dombrowicz (Author), Sandrine Caron (Author), Bart Staels (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Obesity is associated with metabolic dysfunction of white adipose tissue (WAT). Activated adipocytes secrete pro-inflammatory cytokines resulting in the recruitment of pro-inflammatory macrophages, which contribute to WAT insulin resistance. The bile acid (BA)-activated nuclear Farnesoid...