Modifications on the Tetrahydroquinoline Scaffold Targeting a Phenylalanine Cluster on GPER as Antiproliferative Compounds against Renal, Liver and Pancreatic Cancer Cells

• Main Authors: David Méndez-Luna (Author), Loreley Araceli Morelos-Garnica (Author), Juan Benjamín García-Vázquez (Author), Martiniano Bello (Author), Itzia Irene Padilla-Martínez (Author), Manuel Jonathan Fragoso-Vázquez (Author), Alfonso Dueñas González (Author), Nuria De Pedro (Author), José Antonio Gómez-Vidal (Author), Humberto Lubriel Mendoza-Figueroa (Author), José Correa-Basurto (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The implementation of chemo- and bioinformatics tools is a crucial step in the design of structure-based drugs, enabling the identification of more specific and effective molecules against cancer without side effects. In this study, three new compounds were designed and synthesized with suitable abs...