Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFRWT and EGFRT790M inhibitors

• Main Authors: Tarfah Al-Warhi (Author), Ahmed A. Al-Karmalawy (Author), Ayman Abo Elmaaty (Author), Maha A. Alshubramy (Author), Marwa Abdel-Motaal (Author), Taghreed A. Majrashi (Author), Medhat Asem (Author), Ahmed Nabil (Author), Wagdy M. Eldehna (Author), Marwa Sharaky (Author)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Herein, a set of pyridine and pyrimidine derivatives were assessed for their impact on the cell cycle and apoptosis. Human breast cancer (MCF7), hepatocellular carcinoma (HEPG2), larynx cancer (HEP2), lung cancer (H460), colon cancers (HCT116 and Caco2), and hypopharyngeal cancer (FADU), and normal...