Aberrant spliceosome activity via elevated intron retention and upregulation and phosphorylation of SF3B1 in chronic lymphocytic leukemia

• Main Authors: Manoj Kumar Kashyap (Author), Hiren Karathia (Author), Deepak Kumar (Author), Roberto Vera Alvarez (Author), Jose Vicente Forero-Forero (Author), Eider Moreno (Author), Juliana Velez Lujan (Author), Carlos Ivan Amaya-Chanaga (Author), Newton Medeiros Vidal (Author), Zhe Yu (Author), Emanuela M. Ghia (Author), Paula A. Lengerke-Diaz (Author), Daniel Achinko (Author), Michael Y. Choi (Author), Laura Z. Rassenti (Author), Leonardo Mariño-Ramírez (Author), Stephen M. Mount (Author), Sridhar Hannenhalli (Author), Thomas J. Kipps (Author), Januario E. Castro (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Splicing factor 3b subunit 1 (SF3B1) is the largest subunit and core component of the spliceosome. Inhibition of SF3B1 was associated with an increase in broad intron retention (IR) on most transcripts, suggesting that IR can be used as a marker of spliceosome inhibition in chronic lymphocytic leuke...