8-Mercaptoguanine-based inhibitors of Mycobacterium tuberculosis dihydroneopterin aldolase: synthesis, in vitro inhibition and docking studies

• Main Authors: Alexia de Matos Czeczot (Author), Candida Deves Roth (Author), Rodrigo Gay Ducati (Author), Kenia Pissinate (Author), Raoní Scheibler Rambo (Author), Luís Fernando Saraiva Macedo Timmers (Author), Bruno Lopes Abbadi (Author), Fernanda Souza Macchi (Author), Víctor Zajaczkowski Pestana (Author), Luiz Augusto Basso (Author), Pablo Machado (Author), Cristiano Valim Bizarro (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The dihydroneopterin aldolase (DHNA, EC 4.1.2.25) activity of FolB protein is required for the conversion of 7,8-dihydroneopterin (DHNP) to 6-hydroxymethyl-7,8-dihydropterin (HP) and glycolaldehyde (GA) in the folate pathway. FolB protein from Mycobacterium tuberculosis (MtFolB) is essential for bac...