Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo studies

• Main Authors: Mohamed M. Khalifa (Author), Ahmed A. Al-Karmalawy (Author), Eslam B. Elkaeed (Author), Mohamed S. Nafie (Author), Mohamed A. Tantawy (Author), Ibrahim H. Eissa (Author), Hazem A. Mahdy (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This research presents the design and synthesis of a novel series of phthalazine derivatives as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In vitro testing of the new compounds against HepG-2, MCF-7, and HCT-116 cell lines confirmed their potent cytotoxic activity with low IC50 val...