Localized co-delivery of collagenase and trastuzumab by thermosensitive hydrogels for enhanced antitumor efficacy in human breast xenograft

• Autores principales: Anni Pan (Autor), Zhaoyang Wang (Autor), Binlong Chen (Autor), Wenbing Dai (Autor), Hua Zhang (Autor), Bing He (Autor), Xueqing Wang (Autor), Yiguang Wang (Autor), Qiang Zhang (Autor)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Modulation of the collagen-rich extracellular matrix (ECM) in solid tumors by the treatment with collagenase has been proved effective in enhancement of the interstitial transport and antitumor efficacy of antibodies. We, therefore, developed a PLGA-PEG-PLGA polymer-based thermosensitive hydrogel, w...