Localized co-delivery of collagenase and trastuzumab by thermosensitive hydrogels for enhanced antitumor efficacy in human breast xenograft

• Päätekijät: Anni Pan (Tekijä), Zhaoyang Wang (Tekijä), Binlong Chen (Tekijä), Wenbing Dai (Tekijä), Hua Zhang (Tekijä), Bing He (Tekijä), Xueqing Wang (Tekijä), Yiguang Wang (Tekijä), Qiang Zhang (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Modulation of the collagen-rich extracellular matrix (ECM) in solid tumors by the treatment with collagenase has been proved effective in enhancement of the interstitial transport and antitumor efficacy of antibodies. We, therefore, developed a PLGA-PEG-PLGA polymer-based thermosensitive hydrogel, w...