Localized co-delivery of collagenase and trastuzumab by thermosensitive hydrogels for enhanced antitumor efficacy in human breast xenograft

• Main Authors: Anni Pan (Author), Zhaoyang Wang (Author), Binlong Chen (Author), Wenbing Dai (Author), Hua Zhang (Author), Bing He (Author), Xueqing Wang (Author), Yiguang Wang (Author), Qiang Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Modulation of the collagen-rich extracellular matrix (ECM) in solid tumors by the treatment with collagenase has been proved effective in enhancement of the interstitial transport and antitumor efficacy of antibodies. We, therefore, developed a PLGA-PEG-PLGA polymer-based thermosensitive hydrogel, w...