Development of 2-oxindolin-3-ylidene-indole-3-carbohydrazide derivatives as novel apoptotic and anti-proliferative agents towards colorectal cancer cells

• Main Authors: Wagdy M. Eldehna (Author), Mahmoud F. Abo-Ashour (Author), Tarfah Al-Warhi (Author), Sara T. Al-Rashood (Author), Amal Alharbi (Author), Rezk R. Ayyad (Author), Khayal Al-Khayal (Author), Maha Abdulla (Author), Hatem A. Abdel-Aziz (Author), Rehan Ahmad (Author), Radwan El-Haggar (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondrial anti-apoptotic Bcl2 and BclxL proteins, are overexpressed in multiple tumour types, and has been involved in the progression and survival of malignant cells. Therefore, inhibition of such proteins has become a validated and attractive target for anticancer drug discovery. In this manne...