Development of breakthrough bleeding model of combined‐oral contraceptives utilizing model‐based meta‐analysis

• Main Authors: Huili Chen (Author), Dain Chun (Author), Karthik Lingineni (Author), Serge Guzy (Author), Rodrigo Cristofoletti (Author), Joachim Hoechel (Author), Tianze Jiao (Author), Brian Cicali (Author), Valvanera Vozmediano (Author), Stephan Schmidt (Author)
• Format: Book
• Published: Wiley, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Breakthrough bleeding (BTB) is a common side effect of hormonal contraception and is thought to impact adherence to combined oral contraceptives (COCs) but respective dose-response relationships are not yet fully understood. Therefore, the objective of this model‐based meta‐analysis (MBMA)...