Small Molecule-Peptide Conjugates as Dimerization Inhibitors of <i>Leishmania infantum</i> Trypanothione Disulfide Reductase

Small Molecule-Peptide Conjugates as Dimerization Inhibitors of <i>Leishmania infantum</i> Trypanothione Disulfide Reductase

Trypanothione disulfide reductase (TryR) is an essential homodimeric enzyme of trypanosomatid parasites that has been validated as a drug target to fight human infections. Using peptides and peptidomimetics, we previously obtained proof of concept that disrupting protein-protein interactions at the...

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Main Authors: Alejandro Revuelto (Author), Isabel López-Martín (Author), Héctor de Lucio (Author), Juan Carlos García-Soriano (Author), Nicola Zanda (Author), Sonia de Castro (Author), Federico Gago (Author), Antonio Jiménez-Ruiz (Author), Sonsoles Velázquez (Author), María-José Camarasa (Author)
Format: Book
Published: MDPI AG, 2021-07-01T00:00:00Z.
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