Assessing the Effects of VEGF Releasing Microspheres on the Angiogenic and Foreign Body Response to a 3D Printed Silicone-Based Macroencapsulation Device

• Main Authors: Ruth E. Levey (Author), Fergal B. Coulter (Author), Karina C. Scheiner (Author), Stefano Deotti (Author), Scott T. Robinson (Author), Liam McDonough (Author), Thanh T. Nguyen (Author), Rob Steendam (Author), Mark Canney (Author), Robert Wylie (Author), Liam P. Burke (Author), Eimear B. Dolan (Author), Peter Dockery (Author), Helena M. Kelly (Author), Giulio Ghersi (Author), Wim E. Hennink (Author), Robbert J. Kok (Author), Eoin O'Cearbhaill (Author), Garry P. Duffy (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Macroencapsulation systems have been developed to improve islet cell transplantation but can induce a foreign body response (FBR). The development of neovascularization adjacent to the device is vital for the survival of encapsulated islets and is a limitation for long-term device success. Previousl...