E3 ligase activity of Carboxyl terminus of Hsc70 interacting protein (CHIP) in Wharton's jelly derived mesenchymal stem cells improves their persistence under hyperglycemic stress and promotes the prophylactic effects against diabetic cardiac damages

• Main Authors: Ayaz Ali (Author), Wei‐Wen Kuo (Author), Chia‐Hua Kuo (Author), Jeng‐Fan Lo (Author), Michael Y. C. Chen (Author), Jayasimha R. Daddam (Author), Tsung‐Jung Ho (Author), Vijaya Padma Viswanadha (Author), Marthandam Asokan Shibu (Author), Chih‐Yang Huang (Author)
• Format: Book
• Published: Wiley, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Recent studies indicate that umbilical cord stem cells are cytoprotective against several disorders. One critical limitation in using stem cells is reduction in their viability under stressful conditions, such as diabetes. However, the molecular intricacies responsible for diabetic conditio...