A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer

• Main Authors: Karin Stettler (Author), Xiaoming Li (Author), Björn Sandrock (Author), Sophie Braga-Lagache (Author), Manfred Heller (Author), Lutz Dümbgen (Author), Beat Suter (Author)
• Formato: Livro
• Publicado em: The Company of Biologists, 2015-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

XPD functions in transcription, DNA repair and in cell cycle control. Mutations in human XPD (also known as ERCC2) mainly cause three clinical phenotypes: xeroderma pigmentosum (XP), Cockayne syndrome (XP/CS) and trichothiodystrophy (TTD), and only XP patients have a high predisposition to developin...