Revisiting the role of IL-1 signaling in the development of apical periodontitis

• Main Authors: Kento Tazawa (Author), Mariane Maffei Azuma Presse (Author), Hisako Furusho (Author), Philip Stashenko (Author), Hajime Sasaki (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Apical periodontitis (AP) develops as a result of an immune response to pulpal bacterial infection, and various cytokines are involved in the pathogenesis of AP, with Interleukin (IL)-1 being considered a key cytokine. The role of IL-1 in the pathogenesis of AP has been well studied. It is known tha...