Immunothrombosis and Complement Activation Contribute to Disease Severity and Adverse Outcome in COVID-19

• Main Authors: Tiphaine Ruggeri (Author), Yasmin De Wit (Author), Noëlia Schärz (Author), Gerard van Mierlo (Author), Anne Angelillo-Scherrer (Author), Justine Brodard (Author), Joerg C. Schefold (Author), Cédric Hirzel (Author), Ilse Jongerius (Author), Sacha Zeerleder (Author)
• Format: Book
• Published: Karger Publishers, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Severe COVID-19 is characterized by systemic inflammation and multiple organ dysfunction syndrome (MODS). Arterial and venous thrombosis are involved in the pathogenesis of MODS and fatality in COVID-19. There is evidence that complement and neutrophil activation in the form of neutrophil extracellu...