Enhancing both oral bioavailability and brain penetration of puerarin using borneol in combination with preparation technologies

• Main Authors: Tao Yi (Author), Dandan Tang (Author), Fan Wang (Author), Jiqiong Zhang (Author), Jiao Zhang (Author), Jirui Wang (Author), Xiaoyu Xu (Author), Jifen Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Now there are few good oral preparations of puerarin used in cerebrovascular diseases because of its poor oral absorption caused by the low water solubility and the poor penetration into brain. In this study, three oral formulations of puerarin, nanocrystals suspension (NCS), inclusion compounds sol...